Distinct Functions of Human Cohesin-SA1 and Cohesin-SA2 in Double-Strand Break Repair
نویسندگان
چکیده
منابع مشابه
Distinct functions of human cohesin-SA1 and cohesin-SA2 in double-strand break repair.
Cohesin is an essential multiprotein complex that mediates sister chromatid cohesion critical for proper segregation of chromosomes during cell division. Cohesin is also involved in DNA double-strand break (DSB) repair. In mammalian cells, cohesin is involved in both DSB repair and the damage checkpoint response, although the relationship between these two functions is unclear. Two cohesins dif...
متن کاملDistinct roles of cohesin-SA1 and cohesin-SA2 in 3D chromosome organization
Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain Bioinformatics Unit, Biotechnology Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain Centre de Regulació Genòmica (CRG), Barcelona Institute for Science and Technology, Barcelona E-0900...
متن کاملDouble strand break repair.
DNA double-strand breaks (DSBs) are the most dangerous form of DNA damage and can lead to death, mutation, or malignant transformation. Mammalian cells use three major pathways to repair DSBs: homologous recombination (HR), classical nonhomologous end joining (C-NHEJ), and alternative end joining (A-NHEJ). Cells choose among the pathways by interactions of the pathways with CtIP and 53BP1. HR i...
متن کاملCohesin promotes the repair of ionizing radiation-induced DNA double-strand breaks in replicated chromatin
The cohesin protein complex holds sister chromatids together after synthesis until mitosis. It also contributes to post-replicative DNA repair in yeast and higher eukaryotes and accumulates at sites of laser-induced damage in human cells. Our goal was to determine whether the cohesin subunits SMC1 and Rad21 contribute to DNA double-strand break repair in X-irradiated human cells in the G2 phase...
متن کاملMTE1 Functions with MPH1 in Double-Strand Break Repair.
Double-strand DNA breaks occur upon exposure of cells to ionizing radiation and certain chemical agents or indirectly through replication fork collapse at DNA damage sites. If left unrepaired, double-strand breaks can cause genome instability and cell death, and their repair can result in loss of heterozygosity. In response to DNA damage, proteins involved in double-strand break repair by homol...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2013
ISSN: 0270-7306
DOI: 10.1128/mcb.01503-13